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This medication may be available under multiple brand names andor in several different forms. Cases of myopathy, including rhabdomyolysis, have been reported with simvastatin coadministered with , and caution should be exercised when prescribing simvastatin with colchicine. Simvastatin works by blocking an enzyme that helps create cholesterol in the body.
Chinese patients should not receive simvastatin 80 mg coadministered with lipid-modifying doses of niacin-containing products. Before taking this medication, tell your doctor or pharmacist if you are taking other cholesterol-lowering medications such as fibrates (e. The starting dose of this medication depends on your medical conditions and other medications you are taking, and can range from 5 mg to 40 mg taken once daily in the evening.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. Lft elevations to 3x uln andor were discontinued due to transaminase elevations during the 5. Drug treatment also significantly increased the incidence of lung adenomas in mid- and high-dose males and females.
Serum cholesterol and increase during normal pregnancy, and cholesterol or cholesterol derivatives are for fetal development. In a 72-week carcinogenicity study, mice were administered daily doses of simvastatin of 25, 100, and 400 mgkg body weight, which resulted in mean plasma drug levels approximately 1, 4, and 8 times higher than the mean human plasma drug level, respectively (as total inhibitory activity based on auc) after an 80-mg oral dose. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking.
When drug treatment was interrupted or discontinued in these patients, the transaminase levels usually fell slowly to pretreatment levels. Do not take a double dose to make up for a missed one. Because advanced age (65 years) is a predisposing factor for myopathy, including rhabdomyolysis, zocor should be prescribed with caution in the elderly.
Although most of the side effects listed below dont happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. Each tan, oval, biconvex, film-coated tablet, engraved msd 740 on one side and plain on the other, contains 20 mg of simvastatin. The following side effects have been reported by at least 1 of people taking this medication. Moderate (less than 3x uln) elevations of serum transaminases have been reported following therapy with simvastatin. It is important to take this medication exactly as prescribed by your doctor.
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Buy now Zocor 10mg 180 pills in Saguenay Zocor Oral tablet 10mg Drug Medication Dosage information. The risk of myopathy, including rhabdomyolysis is increased by concomitant administration of or danazol. The incidence of rhabdomyolysis (defined as myopathy with a ck 40 times uln) in patients on 80 mgday was approximately 0. If serious liver injury with clinical symptoms andor or jaundice occurs during treatment with zocor, promptly interrupt therapy. Medications other than those listed above may interact with this medication. Of the 7 cases of myopathyrhabdomyolysis among 10,269 patients allocated to simvastatin, 4 were aged 65 or more (at baseline), of whom one was over 75. Each peach-coloured, oval, biconvex, Before taking this medication. The following side effects have been reported by at least 1 of people taking this medication. Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase (ck) above ten times the upper limit of normal (uln).
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Zocor (Simvastatin): Uses, Side Effects, Drug Interactions, Dosage ...
An interaction between two medications does not always mean that you must stop taking one of them. In patients at high risk of coronary events because of existing coronary heart disease, diabetes, peripheral vessel disease, history of stroke or other cerebrovascular disease, zocor is indicated to reduce the need for coronary and non-coronary revascularization procedures. Do not give this medication to anyone else, even if they have the same symptoms as you do. Reduce elevated tg and vldl-c in patients with primary dysbetalipoproteinemia (fredrickson type lll hyperlipidemia). Adolescent patients with heterozygous familial hypercholesterolemia (hefh) zocor is indicated as an adjunct to diet to reduce total-c, ldl-c, and apo b levels in adolescent boys and girls who are at least one year post-menarche, 10-17 years of age, with hefh, if after an adequate trial of diet therapy the following findings are present there is a positive family history of premature cardiovascular disease (cvd) or two or more other cvd risk factors are present in the adolescent patient.
When drug treatment was interrupted or discontinued in these patients, the transaminase levels usually fell slowly to pretreatment levels. If, however, a patient who is currently tolerating the 80-mg dose of zocor needs to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin with less potential for the drug-drug interaction. A pharmacokinetic study with simvastatin showed the mean plasma level of statin activity to be approximately 45 higher in elderly patients between 70-78 years of age compared with patients between 18-30 years of age. Of the 7 cases of myopathyrhabdomyolysis among 10,269 patients allocated to simvastatin, 4 were aged 65 or more (at baseline), of whom one was over 75. If you are a breast-feeding mother and are taking this medication, it may affect your baby.
If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Reduce elevated total cholesterol (total-c), low-density lipoprotein cholesterol (ldl-c), apolipoprotein b (apo b), and triglycerides (tg), and to increase high-density lipoprotein cholesterol (hdl-c) in patients with primary hyperlipidemia (fredrickson type iia, heterozygous familial and nonfamilial) or mixed dyslipidemia (fredrickson type iib). Concomitant use of drugs labeled as having a strong inhibitory effect on cyp3a4 is contraindicated see or telithromycin is unavoidable, therapy with simvastatin must be suspended during the course of treatment. There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including simvastatin. The risk of myopathy, including rhabdomyolysis is increased by concomitant administration of or danazol. Simvastatin is metabolized by cyp3a4 but has no cyp3a4 inhibitory activity therefore it is not expected to affect the plasma concentrations of other drugs metabolized by cyp3a4. It is also used to treat people who have certain inherited cholesterol disorders. For best results in lowering your cholesterol, it is very important that you closely follow the diet suggested by your doctor. Simvastatin lowers the level of total cholesterol and the medication usually takes about 2 to 4 weeks to have a significant effect on the cholesterol level in your blood. The risk of myopathy and rhabdomyolysis is increased by elevated plasma levels of simvastatin and simvastatin acid.Tablets ZOCOR for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or ... The dose of ZOCOR should not exceed 10 mg/day [see WARNINGS AND ..... At 180 mg/kg/day, (which produces exposure levels 22 times higher than those in ..... Two composite endpoints were defined in order to have sufficient events to ...